Ernesto Canalis, M.D., to
Study Notch Signaling in Osteocytes
(Hartford, Conn. March 27, 2013) – Ernesto Canalis, M.D., Director of Research at Saint
Francis Hospital and Medical Center, is the Principal Investigator on a $1,640,000
grant award from the National Institute of Arthritis Musculoskeletal and Skin
Diseases to investigate the Role of Notch
Signaling in Osteocytes over the next five years.
The purpose of the grant is to study a new signal termed Notch and how it affects the function of
specialized cells embedded in the bone matrix, termed osteocytes. Notch determines the fate of bone cells
and has been implicated in diseases affecting both the developing and the adult
“Osteocytes communicate messages to other cells within
the skeleton and play a fundamental role in the maintenance of bone integrity,”
notes Dr. Canalis.
A primary goal of the study is to determine the
functional role played by Notch in
skeletal cells and its possible role in certain forms of osteoporosis and
disorders characterized by bone loss.
For nearly three decades, Dr. Canalis has
been working to unravel the effects of bone growth factors. He was the first
investigator to demonstrate that growth factors play a critical role in bone
In recognition of his contributions to medical sciences, Dr. Canalis has been the recipient of the Ann
Doner Vaughan Kappa Delta Award for Excellence in Orthopedic Research from
the American Academy of Orthopedic Surgeons, the Gerald Aurbach Award for Outstanding Research in Endocrinology from
the Endocrine Society, the Marshall Urist
Award for Excellence in Tissue Regeneration Research from the Orthopedic
Research Society, the Louis V. Avioli
Founders Award for fundamental contributions to bone and mineral basic
research from the American Society for Bone and Mineral Research (ASBMR), and the
Lawrence G. Raisz Award for Outstanding Achievements in Preclinical
Translational Research from the
ASBMR. Dr. Canalis has also served as President of the ASBMR.
Dr. Canalis’ work has been supported by the National
Institutes of Health for over 30 years. His research is highly relevant to
metabolic bone disease and osteoporosis, a major health issue facing men and women
as America’s baby boomers age.
About Saint Francis Care
Francis Care is an integrated
healthcare delivery system established by Saint Francis Hospital and Medical
Center, an anchor institution in north central Connecticut since 1897. Licensed for 617 beds and 65 bassinets, it is
a major teaching hospital and the largest Catholic hospital in New
England. Other major entities of Saint
Francis Care include The Mount Sinai
Rehabilitation Hospital, the Connecticut Joint Replacement Institute, the
Hoffman Heart and Vascular Institute of Connecticut, the Saint Francis/Mount
Sinai Regional Cancer Center, the Joyce D. and Andrew J. Mandell Center for
Comprehensive Multiple Sclerosis Care and Neuroscience Research, and Saint
Francis HealthCare Partners. Its services are supported by a network of
five major Access Centers and eight additional medical office centers sited
throughout the region. For more
information, visit www.stfranciscare.com.
reported in the publication was supported by the National Institute Of Arthritis
And Musculoskeletal and Skin Diseases of the National Institutes of Health
under Award Number R01AR0630049. The content is solely the responsibility of
the authors and does not necessarily represent the official views of the
National Institutes of Health.